[5] The village is nestled into the Chain O'Lakes waterway system and borders the state of Wisconsin.

The Pottawatomi Tribe historically inhabited in the area of present-day Antioch prior to European settlement.

After building a sawmill by Hiram Buttrick on Sequoit Creek, a tributary of the Fox River, the region became a center of commerce.

The town grew as new settlers, primarily of English and German descent, established farms and businesses.

Today, many local businesses and organizations as well as Antioch Community High School use the name "Sequoit".

Partly due to being a regional center of the abolitionist movement, Antioch is noted as having sent a disproportionately high number of its young men to the Union Army.

[citation needed] By the late 1800s, Antioch became a popular vacation spot for Chicagoans and tourism grew quickly once the rail line to Chicago was laid in 1886.

[6] Following World War II, Antioch continued to see a steady population and economic increase, and an industrial park was created in the 1970s.

[12][13] The village lies in a gently rolling moraine landscape, dominated by lakes of glacial origin.

Like Chicago, Antioch lies in a humid continental climate zone and experiences four distinct seasons.

Since 1996, Metra's North Central Service has played an increasingly important role in Antioch's development.

The village continues to undergo commercial and residential growth, mostly along the Illinois Route 173 corridor.

It also hosts concerts in a bandshell, craft fairs, parades, festivals, art walks, and gardening tours.

In 1950 William Schroeder family donated the property located at 757 Main Street to the Village of Antioch for use as a library.

[28] The Chain O'Lakes found along the Fox River, serves as an aquatic mecca for boating and summer leisure while skiing and snowmobiling abound during the winter months.

Along with neighboring Fox Lake, Antioch has become host to numerous pro and amateur national fishing tournaments.

[citation needed] Kite flying is also a popular sporting event on Loon Lake during Labor Day Weekend.

[citation needed] In March 1993, the Antioch Police Department became a part of the Lake County Enhanced 911 system.