Antiochus XIII Philadelphus, (Greek: Ἀντίοχος ΙΓ' Φιλάδελφος) known as Asiaticus, (Ἀσιατικός) was the penultimate ruler of the Seleucid kingdom.

The new king was underage, and his mother, the Ptolemaic princess Cleopatra Selene of Syria, acted as his regent.

[2] Some time after Tigranes had conquered Syria (83 or 74 BC), Antiochus and his brother traveled to Rome to have recognized as kings of Egypt, but to no avail.

[4] In 64 BC, Pompey had Antiochus XIII deposed and killed by a Syrian chieftain, Sampsiceramus I.

[5] Antiochus' death is traditionally said to have ended the Seleucid dynasty, but he was survived by Philip II Philoromaeus for a short time and by Seleucus VII Philometor until 58 BC, if the latter is identified with same prince who briefly married Berenice IV of Egypt.