[3] Before its creation into a regular municipality Antipas was called Buru-Buruan, a sitio of Barangay Kiyaab in Matalam which is inhabited mostly by Manobos.

The name Antipas was derived from "anti" from the word Antique and "pas" from Passi, two places found on Panay Island.

The enthusiasm of the natives and their determination to run their own affairs coupled with the fertility of the soil and a promise of a brighter future of the area made them petition the national government through Governor Carlos B. Cajelo and Assemblyman Jesús Amparo of the Batasang Pambansa.

Antipas being centrally located at the heart of Arakan Valley is protected by Mount Apo from typhoons and bad weather.

Temperature ranges from 23 to 32 degrees Celsius,[9] because of its topographic elevation of 320 meters above sea level and proximity to mountainous Bukidnon province, making it one of the cool places in Soccsksargen.

The palm oil industry is now also in the rise as businessmen and farmers venture further in finding ways on how to utilize their lands effectively.

Coupled with these is the potential of the area for agri-based industries like cassava, coconut and rubber, rice, coffee and cacao.

Public Utility Vans also served routes to and from the municipalities of Arakan, President Roxas, Barangay Linao and Kiyaab of Antipas and Kidapawan City.