Antoine Duquesne (French: [ɑ̃twan dykɛːn]; 3 February 1941 – 4 November 2010) was a Belgian politician and Member of the European Parliament for the French Community of Belgium with the MR/MCC/PRL, Member of the Bureau of the Alliance of Liberals and Democrats for Europe.
Frol 1977 to 1982 he served as general administrator of the National Committee for Coordination and Dialogue on Continuing Education for Small Businesses and the French-Speaking Institute for Continuing Training for Small Businesses.
From 1973 to 1987 Duquesne served as an advisor and chief of staff to various liberal state secretaries and ministers.
In the Verhofstadt I Government Antoine Duquesne served as the Federal minister of the interior (1999–2003).
In 2006 Duquesne had a cerebral infarction which left him paralysed and unable to speak and which prevented him to fulfill his office of member of the European parliament for the remainder of his term or even to resign his mandate, as that formally required his signature, which he no longer was able to give.