[2] In early 1542, Polin successfully negotiated the details of a Franco-Ottoman alliance for the Italian War of 1542–1546, with the Ottoman Empire promising to send 27,500[3] troops against the territories of the Spanish king Ferdinand, as well as 110 galleys[3] against Charles, while France promised to attack Flanders, harass the coasts of Spain with a naval force, and send 40 galleys to assist the Turks for operations in the Levant.

[9] Jerôme Maurand,[10] a priest of Antibes who accompanied Polin and the Ottoman fleet in 1544, wrote a detailed account in Itinéraire d'Antibes à Constantinople.

After they came out of hiding and were reported for sedition, on 1 January 1545 the French king Francis I issued the "Arrêt de Mérindol" and armed a crusade against the Waldensians of Provence.

The leaders in the 1545 massacres were Jean Maynier d'Oppède, First President of the parlement of Provence, and Antoine Escalin des Aimars who was returning from the Italian Wars with 2,000 veterans, the Bandes de Piémont.

In 1571, Polin was involved in the conflict against the Huguenots in La Rochelle as a commander in the French Navy fleet which was making a blockade of the city, together with Filippo di Piero Strozzi.