In the troubles that spread through the south in the wake of the Conspiracy of Amboise he was appointed as 'lieutenant and commander' to help bring order back to Provence and Languedoc.

With peace declared in the Edict of Amboise Crussol did not immediately relinquish power in Languedoc, and held on to his forces until August.

In 1565 the crown raised his lands to a duchy, making him the duc d'Uzès Over the following years he ensured Catholic worship was restored in Nîmes.

[7] Upon the ascent of Charles IX, Crussol was elevated to the Order of Saint Michael and granted a place on the conseil privé.

[9] With word reaching the court of the violent disorder in Provence Crussol was dispatched as a commissioner to work with the governor Tende in suppressing the local civil war that was developing between Catholic militants under Carcès and Protestant under Montbrun.

[13] Throughout the 1560s Crussol would outbid other buyers to snap up alienated church land when it became available in the diocese of Uzès, consolidating his holdings in the region.

[15] The Languedoc estates of November 1562 and March 1563 concerned themselves with building and financing a military defence system to be put under the command of Crussol.

[17] With Condé captured on the field at the Battle of Dreux in December 1562, Catherine took the opportunity to chastise Crussol, urging him to 'remember his duties as the kings subject, and to get his fellow Protestants to disarm.

[19] Catherine protested the fact Crussol remained under arms, urging him to hand his troops over to Guillaume de Joyeuse.

[24] In May 1565, while the king held a lit de justice in Toulouse, he elevated Crussol to the duc d'Uzes , though on the condition that if there was no male heir the duchy would pass to the crown.

Crussol aided the crown in their efforts to subdue the city, however, in the poor conditions of the siege lines he developed an illness, and he died on 11 August 1573.