Most likely Antoine left Arras in the late 1480s, though there is no evidence that he went to Italy, the commonest destination for Franco-Flemish composers of the time.
In the 1490s it is likely he became a priest (although there is no known documentation of that today), and he also may have obtained a master's degree at a university, since he is commonly known as maistre later in his life.
By 1507, he was working as a singer and composer in the chapelle royale for Louis XII of France, who praised him highly.
The Swiss music theorist and biographer Heinrich Glarean, writing in 1547, noted that Févin was a follower of Josquin, and that he died young; he also mentioned him as being a composer of Orleans, though this most likely referred to the association of that city with the court of Louis XII.
Some of Févin's music uses the technique of free contrapuntal fantasy, later perfected by Josquin, where strict imitation is absent; fragments of a cantus firmus pervade the texture, giving a feeling of overall unity and complete equality of all the voices.