In February 2025, Calixto was one of the 95 Lakas–CMD members who voted to impeach vice president Sara Duterte.

He earned his Bachelor of Science degree in Commerce, major in Marketing at San Sebastian College – Recoletos.

He also served in the Pasay Anti-Drug Council, as vice chairman of the Association of Metro Manila Anti-Drug Abuse Council, and as the public relations officer and a member of the board of directors of the Vice Mayors' League of the Philippines, National Capital Region.

Consuelo "Connie" Dy, and Ricardo "Ding" Santos, former security aide of former Mayor Pablo Cuneta.

He is one of the 70 lawmakers who voted (representing Malabon Rep. Josephine Lacson-Noel) to reject the franchise renewal of ABS-CBN.

He is the older brother of Mayor Imelda Calixto-Rubiano and uncle of District 2 Councilor Jose Isidro Jr. Calixto married Edna Dayrit Aguas, with whom he has three children: Mark Anthony (incumbent councilor from the 1st district), Derek, and Charlene.