Along with Domingo French, he led a group of revolutionaries known as the Chisperos, who played a pivotal role in the Semana de Mayo, the week beginning on May 18, 1810, which culminated in the May Revolution.

In the Cabildo Abierto of May 22, he voted for the deposition of the viceroy Baltasar Hidalgo de Cisneros and was the most fervent opposer to a Junta presided over by him.

Miguel de Azcuénaga, Hipólito Vieytes, and Nicolás Rodriguez Peña were forced to resign and subsequently exiled from Buenos Aires.

Beruti then participated in the Chile campaign alongside General José de San Martín in early 1817, and fought in the Battle of Chacabuco.

On March 13, 1817, Bernardo O'Higgins, at the request of San Martín, asked Beruti to return to the city of Mendoza and arranged his passport with governor Luzuriaga.