During his years at the university, he began his involvement in politics by becoming a member of Nuevas Generaciones, the youth organization of the People’s Party.

During this term, López-Istúriz, was the MEP who received the most visitor groups, including university students, entrepreneurs, young people and retirees.

López-Istúriz was rapporteur on the proposal for a Regulation of the European Parliament and of the council on cableway installations, and alternative rapporteur for the report on EU-China relations and on reports for which the Parliament issues an opinion "Establish a new agreement for energy consumers" and "European Energy Security Strategy".

In 2002, under the leadership of the President of the Government of Spain at the time, José María Aznar, he was elected Executive Secretary of the Centrist Democratic International (IDC-CDI), which brings together 100 political parties from 49 countries.

IDC-CDI maintains his commitment to the defense of democracy and the denunciation of violations of Human Rights, particularly in Cuba, Venezuela and Nicaragua.

The IDC regularly produces declarations and consensus documents, addressing the defense of Human Rights and the promotion of democracy at an international level.

He was also one of the promoters of the Written Declaration on Investing in Children which was approved on December 7, 2015, with 428 signatures from MEPs, a record number in the European Parliament.

http://www.childrightsmanifesto.eu/ Since 2000, he has been Vocal of the Board of Trustees of the AEQUITAS Foundation, an organization created by the General Council of the Spanish Notaries in order to provide free legal services to people who for reasons of age, physical or mental illness, or membership of certain socially-disadvantaged groups, are in need of special protection.

Within the scope of his parliamentary activity, he was rapporteur of the European Parliament report that addressed issues such as vulnerability in old age and measures to support the elderly and disabled.

Along with the latest two and with former congressman Lincoln Díaz-Balart, he has developed initiatives and activities in favor of Cuban democracy, a subject about which he is extremely passionate.

[2] López-Istúriz has always been very active in the promotion of democracy in Cuba and Venezuela, and has been vocal in his support for Cuban dissidents and Venezuelan opposition.