After subsequently establishing himself as a starter, he helped his side to achieve promotion in the 1989–90 season as champions by scoring the only goal against Los Andes in the decisive match.

During that campaign, he scored ten goals as Huracán finished one point shy of a Copa Libertadores play-offs in the Clausura tournament.

In 1991, Mohamed was sold to Serie A side Fiorentina for US$1.2 million,[3] but was successively loaned to Boca Juniors and Independiente back in his home country.

His career apexed with Toros Neza when they had made it to the final against Guadalajara in the Verano '97 season alongside other famous players at the time such as Nildeson, Rodrigo Ruiz, and Germán Arangio.

[18] Mohamed would return to Mexico in 2011, and on 19 September of that year, he was announced as the new manager of recently promoted Club Tijuana, replacing Joaquín Del Olmo.

[25] At the press conference it was revealed that he had signed a one-year contract with the club, with the potential for an extension pending a review of his performance.

[30] Following three consecutive victories against León, Atlas, and Atlante, América suffered defeats to Pachuca and Morelia, both 0–1, the first time they had lost back-to-back games since the Clausura 2012 tournament.

[33] On 23 February, América were defeated 1–3 by Pumas in the Mexico City derby, ending the club's two-year hegemony over their intracity rival.

[35] They would ultimately be eliminated in the quarterfinals by Santos Laguna with a 6–6 aggregate score (América won the first leg 5–3, but lost the second 1–3), with the away goals rule deciding the series.

These instances usually involved long weekend getaways to support Argentina at the 2014 FIFA World Cup Final and going to Europe for an all-star "peace match" for the Pope, among other circumstances.

[citation needed] A few days before the first leg of America's semi-final match against Monterrey, Mohamed dismissed club co-captain Paul Aguilar after an undisclosed locker room incident.

[citation needed] The club morale was further affected once players Luis Angel Mendoza and Jesus Molina were confirmed to be transferring teams before playoffs had ended.

Mohamed remained in charge of the Rayados in the following seasons, taking the club to the CONCACAF Champions League twice (2016 and 2018), but still being knocked out by Panamanian side Árabe Unido in the 2016–17 group stage.

[50] On 20 February 2022, Mohamed won his first title with the club, by beating Flamengo in the penalty shootouts of the Supercopa do Brasil match.

[51] On 2 April 2022, Mohamed won his second trophy with Atlético, beating arch rivals Cruzeiro in the Campeonato Mineiro final with a 3–1 score.

[52] He left the club on 22 July 2022, following a string of poor results in the Campeonato Brasileiro and an exit in the round of 16 of the Copa do Brasil.