In 1644, as a young adult, he was sent by his father in charge of a large navy to settle and fortify Corral Bay at the entrance of the ruins of Valdivia.

Arriving at Corral Bay in February 1645 the men in charge of Antonio de Toledo commenced construction of a system of defensive fortifications.

[3] He returned to Spain with his father in 1648, and was subsequently majordomo of the royal palace, and then ambassador in Venice and Germany.

While in Chapultepec he gave orders that no celebration was to accompany his arrival, because the treasury of the colony had been exhausted by remittances to Spain and the war against the English.

The viceroy and his wife, the virreina, became patrons of the seventeenth-century nun and savant, Sor Juana Inés de la Cruz.

In other actions, the viceroy inspected the fortifications of San Juan de Ulúa, near Veracruz, and suspended work on the drainage system of Mexico City and the construction of a convent in Guanajuato for lack of money.

He supported the marriage of the King with Maria Anna of Neuburg and obtained the royal favour of Grandee of Spain in his personal capacity on 17 February 1687, and perpetual for the Marquisate of Mancera five years later.

[6] Once the time of the succession to the throne of Spain arrived, he was first a supporter of the House of Austria, finally opting for Philip V of Spain, representative of the House of Bourbon, who in reward for his services named him president of the Council of Italy in 1701 and included him in the Government Board of the Kingdom in 1703.

The Marquis himself had attributed the reason for his longevity to the properties of chocolate, a food that he, like his father, consumed in large quantities.