The earliest mention of Il Pastura occurs in December 1478, when the artist participated in the establishment of Foundation of Art and University of San Luca dei Pittori, in Rome.
After that, he traveled to Orvieto, where it is documented that between 1497 and 1499 he completed the restoration of frescoes originally painted by Ugolino di Prete Ilario for the cathedral, work which had been started by Pinturicchio.
For that Cathedral, il Pastura worked on pieces that featured Biblical scenes such as the Annunciation, Visitation, Presentation to the Temple, and Flight into Egypt.
He created frescoes in Viterbo such as Santi Giovanni Battista, Girolamo e Lorenzo (Saints John the Baptist, James, and Lawrence) for the baptistery of Santa Maria Nuova, which was possibly influenced by the work of Antoniazzo Romano and Perugino.
The Italian scholar Italo Faldi has observed the success with critics that Il Pastura's work has enjoyed.