In the following years he returned to Naples several times, and received medical training, and studies of humanism from some of the leading cultural representatives including Antonio Beccadelli, Giovanni Pontano and Giacomo Sannazaro.

This student shared fully the method of investigation, the distrust of the sterile disputes of philosophers over the Alps, and he argued the need to read the classics in bare text, without the use of exegetical apparatus.

In the decade of 1470-1480 Galateus lived more permanently in Salento, where in 1478 he married Maria Lubelli dei baroni of Sanarica and together they had five children, Antonino, Betta, Galieno, Lucrezia and Francesca.

Galateus tried to revive him education lessons in the Accademia lupiensis in Lecce or Bari in the small court of Isabella of Aragon, daughter of Alfonso II of Naples, there he exchanged letters in later years with the latest generation of academics including Belisario Acquaviva, Pietro Summonte, Crisostomo.

In 1510 Galateus visited Pope Julius II, in Rome with a manuscript copy of the donation Constantine extracted from the library of San Nicola di Casole in Otranto.