Governor Guill y Gonzaga celebrated the "Parliament of Nacimiento" with the Mapuches in 1764, where he tried to impose his scheme to make them live in towns.
This provoked the Mapuche uprising of 1766 under the command of the toqui Curiñancu, which lasted until Agustín de Jáuregui made a peace in 1774.
In addition he was ordered to carry out the expulsion of the Jesuits on August 27, 1767, from Chile.
In 1765 he founded the Villa San Luis Gonzaga de Rere and Tucapel Nuevo, the following year San Carlos de Yumbel was founded, all of them in the region of Concepcion.
He was succeeded by Juan de Balmaseda y Censano Beltrán as the interim governor.