Like most of the previous doges, Antoniotto was a merchant by trade; he was also reputed to be well-versed in law and literature and he is known to have pleaded in at least one case as an attorney.

The same year he managed to force his former accomplice out of office but he failed to win the ensuing elections; he was, however, allowed to remain in Genoa and entered the council of the Ancients.

He gave refuge to the controversial pope Urban VI in 1386, and the following year he obtained a peace treaty with the Aragonese king and mounted with him an assault against Barbary raiders under the command of his brother, Raffaele.

On 3 August 1390 he was forced out of office by the armed partisans of Giacomo Fregoso, son of the former doge Domenico di Campofregoso.

Backed militarily by Gian Galeazzo Visconti, he attempted to re-conquer his position but was defeated by the new doge, Antoniotto Montaldo.

[1] A new danger arose when, on 17 November 1394, confronted with internal strife and rather than remaining under Genoese domination, the neighbouring city of Savona gave itself to the king of France.

[1] On 18 March 1397 Antoniotto relinquished his position of governor and went into retirement on the estates of the marquis Del Carretto in Finale Ligure.