Antrodia species have fruit bodies that typically resupinate (i.e., lying flat or spread out on the growing surface), with the hymenium exposed to the outside; the edges may be turned so as to form narrow brackets.

Antrodia are effused-resupinate, that is, they lie stretched out on the growing surface with the hymenium exposed on the outer side, but turned out at the edges to form brackets.

Typically, basidiospores are thin-walled, cylindrical, and narrowly ellipsoidal or fusiform in shape.

The modern definition of the genus follows the description given by Gilbertson and Ryvarden (1986), in their monograph North American Polypores.

[8] In order to reliably identify the various species and strains of medicinal Antrodia, genetic markers have been developed and phylogenetic analyses performed.