Antsampanana [vatʷˈmanɖʐʲ] is a village in Atsinanana Region, Madagascar.

It is located along Route Nationale (RN) 2, at the northern terminus of RN 11 (which heads south to Vatomandry).

A memorial dedicated to the victims of the Malagasy Uprising of 1947 was erected in the village centre.

There is a small mosque in Main Street.

Antsampanana's market area is a common stopping point for trips.