[8][9] According to one hypothesis it originates from Bosnia as one of the Bosnian noble families that had moved to Šibenik in the era of Ottoman military incursions of the 15th century,[10] or before due to some political events.

[9] There the family was allegedly ennobled with lilies in coat of arms by Louis I of Hungary (noble status confirmed later only in the 16th century),[9] and following the Ottoman conquest of Bosnia, only certain Ivana Vrančić and his wife and children escaped.

[9][12] Antun Vrančić, in a letter to Hasan-beg Sancakbey of Hatvan in 1559, states that they both are born as Croats and the shared Croatian ethnicity brings them closer together.

[18] Antun had seven brothers and two sisters from his mother Margareta and stepmother Angelica/Anđelika Ferro, by letters was most closely connected to Michaele/Mihovil (1507/13-1570/71), Piero/Petar (1540-1570) and Giovanni/Ivan (1535-1558),[19][20] but also nephews Faust (1551-1617), Kazimir Vrančić (1557-1637), Jeronim Domicije-Berislavić (b. c. 1533) among others.

[21] Vrančić's uncle by mother side Ivan Statilić and his other relative, Croatian viceroy Petar Berislavić, took care of his education.

[22][3] His maternal uncle, János Statileo, Bishop of Transylvania also supported him in Trogir, Šibenik, from 1514 in Hungary and in Padua, where he earned the degree of magister in 1526.

[4] Later in his life was guardian and took care of younger brother Jerolim and Ivan, and nephews Faust Vrančić and Jeronim Domicije education.

[25] In 1541 he moved with her to Transylvania, but he mostly traveled fulfilling diplomatic services because of his disagreement with cardinal Juraj Utješinović's policy of claiming the Hungarian throne for Isabella's and Zápolya's infant son (instead of conceding it to Ferdinand I as per the Treaty of Nagyvárad).

In parallel to his diplomatic duties, he held important positions in the Catholic Church (chief dean of Szabolcs County and abbot of Pornó Abbey).

During his stay in Istanbul, together with Ogier Ghislain de Busbecq, Vrančić discovered Res Gestae Divi Augusti (Eng.

[22] Vrančić was in touch with German philosopher, theologian and reformer Philipp Melanchthon (1497–1560); and with Nikola Šubić Zrinski (1508–1566), Croatian ban, poet, statesman and soldier.