A secondary school with a continuity up till the present-day was opened as Realgymnasium in 1909, while Šibenik and Croatia were a part of Austria-Hungary.

After the war, the school was restructured and named after People's Heroes of Šibenik (Ljubo Truta, Miro Visic, Vlado Peran, Slobodan Macura).

In 1991 it was again remodelled as a general high school and named after Antun Vrančić (1504-1573), renaissance humanist, cardinal, diplomat and author from Šibenik.

[3] School's students also participated in International Mathematical Olympiad twice - in 2001 in Washington, DC and in 2002 in Glasgow, where they won a bronze medal.

[4] In 2007 and 2011, Antun Vrančić students competed at International Philosophy Olympiad in Turkey and Austria, respectively, earning an honorable mentioning.