Built in 1880 by the Wabash, St. Louis and Pacific Railway,[1] it is a primarily wooden structure with weatherboarded walls.

[3] When the depot was built, Antwerp was the largest community in Paulding County, due to an active logging industry.

Inside, the station is divided into several distinct areas: freight, ordinary passengers, mail and express packaging, and internal railroad offices; each possess their own rooms.

Other than its size, the depot is typical of late nineteenth-century train stations in northwestern Ohio, which frequently served as commercial hubs for their communities.

[2] This designation is unusual, for buildings that have been moved from their original locations are not normally eligible for inclusion on the National Register.