[6][7] Since October 2024, the series stars Ganguly with Adrija Roy (replaced Alisha Parveen Khan) and Shivam Khajuria as second generation leads.

Tapish reveals his traumatic childhood where his mother accidentally killed his abusive father in an attempt to save him and later surrendered herself and went to jail.

At the same time, Dimple turns insecure seeing Ansh's growing fondness with Aadhya and Dolly takes it as an opportunity to fuel it more after Tapish shifts to Mumbai.

On the other hand, Ankush, who is greedy over his power over the Kapadia Empire, reaches Himachal and attempts to kill Anuj by hitting him with a rock and throwing him off the cliff.

Kinjal's insecurities grow regarding Aarya's future despite her being a fashion designer as she watches Pakhi groom Ishani into a successful model while Dolly too lives in a fear for being punished for her deeds done with Aadhya & wishes that the latter never arrives back.

Aadhya's growing fondness with Ansh starts making Mahi insecure while former decides to return Dwarka after paying off Anupamaa's debt.

[15] On 14 October 2024, the show took its first generation leap of fifteen years, showcasing Anuj's death and focusing on grown-up Aadhya and Prem along with Anupamaa.

[42] Also that month, Varun Sharma was cast to play a cameo as Nandini's ex-boyfriend and obsessive lover Rohan and he finished off his role in October 2021.

[50] During that month, Aneri Vajani announced her decision to participate in Fear Factor: Khatron Ke Khiladi 12 and quit the series permanently.

[58] Child artist Asmi Deo was also cast as an orphan Anu but her track was put on hold and resumed in July 2022 as Anuj and Anupamaa's adopted daughter.

[59] In July 2022, Paras Kalnawat signed on to appear on the dance-based reality show Jhalak Dikhhla Jaa 10 on rival network Colors TV.

[60] Kalnawat revealed that "after Bhosale's exit his character never evolved, and that he was unhappy with his role being reduced to a mere family member standing in background with nothing to do anything.

[64] In September 2022, Alma Hussein who was cast opposite Kalnawat also quit the series, saying she was unhappy with the lack of character development and shot her last scene in early August 2022.

However, Jaiswal exited the show in the same month because his role was only a cameo appearance of Dimple's husband who abandons her after her rape and Saxena went on to be paired with Sagar Parekh.

In January 2023, actress Chhavi Pandey was cast to do an extended cameo of Anu's biological mother, Maya, who wrapped up in July 2023 following her character's death.

[67] In May 2023, Apara Mehta was cast as Anuj's mother Malti Devi, while her daughter Khushali Jariwala played her younger version on screen and she quit the series prior to the first leap in December 2023.

[68][69] In August 2023, Ekta Saraiya, who portrayed Vanraj's sister Dolly, quit the series for her show Kyunki... Saas Maa Bahu Beti Hoti Hai on Zee TV.

[75] The same month Muskan Bamne portraying Pakhi quit the series after 3 years as "she doesn't wish to play mother at such a young age and wants to move ahead in her career"[76] and was later replaced by Chandni Bhagwanani[77] while child actor Aadhya Barot was cast as her daughter Ishani Mehta the same month.

[87] On 28 August 2024, Sudhanshu Pandey announced his decision to quit the series after playing it for four years via his Instagram handle and said "his last appearance was in Raksha Bandhan special episodes and he will continue entertaining his audience through new roles.

[90] Later she said about Rupali Ganguly "being two-faced and speaking about her on back which hurted her genuinely" thus confirming the earlier reported split amongst cast members in 2021.

[94][99][100] Chandni Bhagwanani too announced her exit from the show prior to the leap as she too "didn't wanted to play mother to a 22-years-old Ishani" and got replaced by Krutika Desai as older Pakhi.

[101][102][100] Child actors Trishaan Shah, Princy Prajapati, Aadhya Barot and Pahal Chaudhary got replaced by Varun Kasturia, Ishita Modi, Vidushi Tiwari and Spreha Chatterjee as grown-up Ansh, Aarya, Ishani and Mahi respectively.

[108][109][110] while Mazher Sayed who earlier worked with the production house in 2015 in another show Yeh Rishta Kya Kehlata Hai and Shiwani Chakraborty joined in as Prem's uncle and aunt.

[111]Saee Barve from Yeh Rishta Kya Kehlata Hai, entered as Prem's late mother, Gayatri Kothari.

[116][117] On 2 April 2021, Rupali Ganguly, Sudhanshu Pandey and Aashish Mehrotra who portray Anupamaa, Vanraj and Paritosh respectively and producer Rajan Shahi tested positive for COVID-19.

[118][119] A few days later, Tassnim Sheikh, Alpana Buch and Nidhi Shah also tested positive for COVID-19 and the story focussed more on Samar, Nandini and Pakhi's characters.

[123] On 14 November 2024, a 32-years-old crew member, Vineet Kumar Mandal who worked as a camera attendant died of electrocution whilst filming.

Following which AICWA lodged a case against the production house for negligence in safety measures of crew members on sets and trying to suppress the matter by being backed by the channel.

[138] ThePrint appreciated the series, along with few other Hindi GECs based on the story of a mother, mentioning that it delivered moral lessons and calling the character Anupamaa a paragon of virtue and farcical.

The Times of India stated, "Now, fans have taken to their Instagram handles to find the exact same scene from the show Yeh Rishta Kya Kehlata Hai when "Akshara" (Hina Khan) reunited with "Naira" (Shivangi Joshi) after a leap.