[4] She went to Indira Gandhi Memorial Vocational Higher Secondary School, Manjakala, Kollam.

Anusree impressed director Lal Jose while he was judging the acting reality show Vivel Active Fair Big Break on Surya TV,[5] in which she was competing,[6] leading to her film debut as Kalamandalam Rajasree in Lal Jose's 2012 film Diamond Necklace.

[7][8] In 2016 she appeared in Dileesh Pothan's Maheshinte Prathikaaram and as Police ACP Ganga in Priyadarshan's Oppam.

She went on to star in films such as Kochavva Paulo Ayyappa Coelho (2016), Oru Cinemakkaran (2017), Aadhi (2018), and Panchavarnathatha (2018).

Anusree was initially cast in the female lead role in Pulimurugan (2016), opposite to Mohanlal.