Indy, Any Given Saturday was sired by the increasingly important stallion Distorted Humor, who produced 2003 Kentucky Derby and Preakness Stakes winner Funny Cide.

Consigned to the September 2005 Keeneland yearling sale, he was sold for $1.1 million to WinStar Farm and partnered to Padua Stables, who entrusted his race conditioning to the United States' leading horse trainer, Todd Pletcher.

Racing as a three-year-old, Any Given Saturday won his first outing in the February 2007 Sam F. Davis Stakes followed by a strong second to Street Sense in the Tampa Bay Derby.

On September 22, 2007, Any Given Saturday won the Brooklyn Handicap by 2½ lengths as the favorite over Tasteyville and Helsinki, topping $1 million in career earnings.

Sheikh Mohammed's Darley Stud at Jonabell, near Lexington, Kentucky, announced that Any Given Saturday would be retired to stand for $40,000 live foal for the 2008 season.