She began her career in a 2017 production of the play Much Ado About Nothing at Shakespeare's Globe, and made her screen debut with BBC dramas Wanderlust and The ABC Murders in 2018.

[13][14] Her first on screen role came in 2018 when she portrayed Jennifer Ashman in the BBC comedy-drama, Wanderlust, alongside Toni Collette.

The same year, she appeared as Lily Marbury in BBC’s adaptation of Agatha Christie’s The ABC Murders, starring John Malkovich.

[15] In October 2018, it was announced that Chalotra had been cast in the main role of Yennefer alongside Henry Cavill as Geralt and Freya Allan as Ciri in Netflix series The Witcher,[16] an adaptation of the fantasy novels by Andrzej Sapkowski.

[22][23] On 15 July, it was announced that she would be headlining the voice cast of the sci-fi animation series New-Gen.[24] On 30 September, she starred in a short film called No Masks that aired on Sky Arts, based on real-life testimonies of key frontline workers in East London during the COVID-19 pandemic.