Anzême (French pronunciation: [ɑ̃zɛm]; Occitan: Anzesme) is a commune in the Creuse department in the Nouvelle-Aquitaine region in central France.

An area of farming and quarrying, comprising the village and several hamlets situated by the banks of the Creuse, some 7 miles (11 km) north of Guéret, at the junction of the D14 and the D33.