Aoife McLysaght is an Irish geneticist and a professor in the Molecular Evolution Laboratory of the Smurfit Institute of Genetics, Trinity College Dublin in Ireland.

[1][3][4][5] McLysaght was educated at the Trinity College Dublin where she was awarded a Bachelor of Arts degree in Genetics in 1998, followed by a PhD in 2002 for research supervised by Kenneth H. Wolfe on the evolution of vertebrate genome organisation.

Her research in molecular evolution and comparative genomics[1] has been published in leading peer-reviewed scientific journals including Nature,[10] Nature Genetics,[11] Bioinformatics,[12] Genome Research,[13] PNAS[14][15] and the journal Yeast.

[17] McLysaght is a regular contributor to public events, and has spoken at IGNITE Electric Picnic,[18][19] TEDx, The Royal Institution, and on the BBC Radio 4 programme The Infinite Monkey Cage.

In 2018 she joined with Alice Roberts to write and present the televised Royal Institution Christmas Lectures.