She has had recurring roles on television series including BoJack Horseman and Corporate and has written for Late Night with Seth Meyers[2] and Totally Biased with W. Kamau Bell.

Nancherla released her debut comedy album Just Putting It Out There through Tig Notaro's Bentzen Ball Records on July 8, 2016.

[6] She grew up outside Washington, attending Thomas Jefferson High School for Science and Technology in Fairfax County, Virginia.

Nancherla moved to Los Angeles, then to New York City to write for Totally Biased until the show's cancellation in 2013.

[10][4] In 2019 she was featured in Laughing Matters, a 30-minute YouTube documentary created by SoulPancake in collaboration with Funny or Die wherein a variety of comedians discuss mental health.

"[14] She is also the co-host of Blue Woman Group, which the Daily Beast calls "a hilarious podcast about depression.

In the Bob's Burgers season 9 episode "UFO No You Didn't", which aired in December 2018, she voiced Susmita,[26] Tina's science partner.