[4] Due to the new format of the CONCACAF Champions League, Mexican clubs do not begin their participation until February, thus the teams qualified to 2017–18 CONCACAF Champions League (América, Guadalajara, Tijuana, UANL) will participate in this season's Copa MX.
[4] The draw for the tournament took place on June 6, 2017, in Cancún, Quintana Roo, Mexico.
[6] Clubs in Pot 1 were drawn to be the seed of each group according to the order of their drawing.
[8] Pot 3 contained Liga MX clubs who ended 10–17 in the Aggregate table.
[6] UDG, who ended twelfth in the Ascenso MX Aggregate table, replaced recently promoted Lobos BUAP.