The Applegate Drugstore is a historic commercial building at 116 South First Street in Rogers, Arkansas.

It is a two-story masonry building, with brick sidewalls and a limestone facade.

The second floor has two large bays, each with a pair of sash windows, delineated by Corinthian pilasters.

The interior of the store retains original drugstore furnishings, including a pressed tin ceiling, tile floor, walnut shelving, and a polished marble fountain counter.

This article about a property in Benton County, Arkansas on the National Register of Historic Places is a stub.