Appleton is a ghost town in Persifer Township, Knox County, Illinois, United States.

Court Creek also flows through Appleton before its confluence with the Spoon River in Dahinda.

It is situated on the north side of the Atchison, Topeka and Santa Fe Railway and is a station on that road.

In the early years of the time, Appleton became known for grain and stock exporting.

[citation needed] A volunteer fire department serves the Appleton area.