"[1] A review of reported cases has shown a 2:1 female to male occurrence, and onset usually in the sixth decade of life.
[2] A person with ALO may complain of occasionally being unable to open the eye at will, typically after prolonged closure.
Hypometabolism of glucose may play a part, and has been documented in the basal ganglia, frontal lobe, and the primary visual cortex in some cases of ALO.
Computed tomography (CT) or magnetic resonance imaging (MRI) may be ordered to help determine whether there is a lesion or other pathological cause present in the brain or brainstem.
[22][23] Levodopa has been reported to improve symptoms in patients with Parkinson's disease and progressive supranuclear palsy.