Her process includes typelayering, where words and letters are sandwiched and layered, but also appear to float along with other 'objects in space' such as: color swatches, illustrations, lines, mapping, photographs, shapes, among other visual assets.

She creates a sense of depth and dynamism, in particular, by combining graphic elements through making extensive use of Apple Macintosh technology.

"[5] Born on March 22, 1948, metropolitan New York, April Greiman grew up in Wantagh, Long Island and later Woodcliff Lake, NJ.

Upon Greiman's relocation from New York City to Los Angeles, she met designer-photographer Jayme Odgers, who became a significant collaborator.

In 1981 they created an iconic poster of running legs silhouetted against a square of bright blue sky that was published in 1982 in advance of the 1984 Olympics.

[19][20] In 1986, Greiman was invited by The Walker Art Center to produce Issue 133 of Design Quarterly entitled: Does It Make Sense?

Using MacVision, a combination hardware/software interface to digitize still frames from a video camera or VCR,[23] Greiman re-imagined the magazine as a fold-out artwork.

[25] In 1988 in MacWorld's[26][circular reference] First Annual Mac Masters Art Competition, Greiman was awarded Fine Arts First Prize (A) for her Pacific Wave Sculpture,[27] a project produced for the Fortuny Museum in Venice, Italy, for the museum's Pacific Wave Festival, an exhibition celebrating California graphic designers September 27 – December 27, 1987.

Innovatively restored and turned it into a retreat showcased their three-dimensional design as an oasis of the spirit with "pool and buildings with a purity equal to the desert's.

[38] With four honorary doctorates, April Greiman is seen as one of the "ultimate risktakers" for her unorthodox and progressive approach to design by embracing new technologies.

[54] In 2007, Greiman completed her largest ever work: a public mural, Hand Holding a Bowl of Rice, spanning "seven stories of two building facades marking the entrance to the Wilshire Vermont Metro Station in Los Angeles.

"[55] In 2014, Greiman collaborated with the London based artist-run organization Auto Italia South East along with a group of artists including Metahaven, in an exhibition POLYMYTH x Miss Information.