Aquiminzaque‘s reign began on August 2, 1537, when Eucaneme was taken prisoner to Suesca by the Spanish.

At first Aquiminzaque converted to Catholicism, but when he realized the true motives of the Spanish conquerors over the Muisca people, he revolted against them, undermining the initial rule of Hernán Pérez de Quesada, brother of Gonzalo Jiménez de Quesada.

Shortly after, in 1540, Hernán executed Aquiminzaque by public decapitation in Tunja.

[3] The spectacle, meant as an example, was watched by the Muisca people and executions of other caciques of Toca, Motavita, Samacá, Turmequé and Sutamarchán followed.

In Tunja, the capital of the Boyacá department, a statue honouring Aquiminzaque (Monumento a la Raza Indígena) has been erected.