[2] Ramírez struggled in his first three seasons, splitting playing time between the Pirates and Triple-A Nashville Sounds.

During the first inning of Game 4 of the NLCS, Ramírez hit the first playoff grand slam in Cubs history off Marlins starter Dontrelle Willis.

On September 16, 2004, Ramírez became the 14th player in Major League history to have two different games with three home runs in a season.

Ramírez finished the season on the disabled list, after straining his quadriceps femoral muscle on August 24.

On June 29, 2007, Ramírez had one of the best games of his career, in which he went 3-for-5, highlighted by ending a crucial game against the Milwaukee Brewers with a two-out, two-run home run in the bottom of the ninth inning off pitcher, Francisco Cordero to cap a five-run comeback win.

On June 20, in the bottom of the ninth inning, during the first game of the 2008 Crosstown Classic against the Chicago White Sox, Ramírez hit his 2nd home run of the day for a walk off.

On May 8, Ramírez dislocated his left shoulder while fielding a ground ball in a game against the Milwaukee Brewers.

[7] Ramirez began the season fairly slowly, batting .168 with five home runs and 22 RBIs through his first 47 games before landing on the 15-day disabled list on June 9 with a bruised thumb.

[10] On July 10, 2011, Aramis Ramírez was asked by National League manager Bruce Bochy to replace Plácido Polanco in the All-Star Game, but Ramirez declined the invitation due to previous plans to be with his family during the break.

[11] On October 30, 2011, Ramirez declined his portion of the $16 million option on his contract and chose to become a free agent.

In his ninth season as a Cub, Ramirez batted .306 with 35 doubles, 26 home runs and a team-high 93 RBIs.

Ramirez was a top-five finalist for the NL Gold Glove Award in his first season as a Brewer, dramatically improving his fielding abilities and becoming one of the best infield defenders in baseball.

Ramirez returned to play in May and June, but was hampered by the knee injury causing him to lack lateral movement at 3rd base and diminished his signature power.

The injury developed into patella tendinitis forcing Ramirez into another 30-day stint on the Disabled List by the end of July.

[16] On July 23, 2015, Ramirez was traded back to the Pirates in exchange for minor league pitcher Yhonathan Barrios.

Ramírez formally announced his retirement from MLB on November 5 but added that he hoped to play one final season in the Dominican Winter League with los Tigres del Licey.