[7] In October 1118, Pope Gelasius II arrived in Genoa from Pisa, having fled from the violence of the Frangipani family in Rome.

Meanwhile, in Milan, Archbishop Anselm had announced his support for Pope Anacletus, though a substantial number of Milanese objected to his choice and campaigned for Innocent.

The opposition was led by the Archpriest, Stephanus Guandeca, who brought the people around to repudiating Anacletus, recognizing Innocent, and deposing Anselm.

The Annales Genuenses of Caffaro di Caschifellone, a contemporary of Bishop Syrus, states that Pope Innocent was present when Syrus was elected Bishop of Genoa, but that he was consecrated in the same year by Pope Innocent at Sanctus Egidius (near the later city of Montpellier).

[11] At the time of his election as bishop, Syrus was already a Cardinal of the Holy Roman Church,[12] having been named by Innocent himself earlier in the year 1130.

[14] Five days later, the Pope wrote again, extending the use of the pallium and naming Syrus and his successors Commendatory Abbots of the monastery of S.

In 1292, Opizzo Fieschi resigned, and Pope Nicholas appointed Jacobus de Voragine to the Archbishopric of Genoa.

[19] Urban VI, who represented the "Roman Obedience" at the beginning of the Great Western Schism (1378–1417), had been intriguing to set up a principality for his nephew Butillo in the Kingdom of Naples.

In response Urban imprisoned and tortured six cardinals, but Charles responded by besieging the Pope in the town of Nocera (Lucera).

He broke his way in, extracted money from the inhabitants, and made arrangements with the captains of the Genoese galleys who were standing off Naples to take his party on board and convey them to Genoa.

The earliest known diocesan synod took place in 1216, according to Jacobus de Voragine, immediately after the return of Bishop Otto from the Fourth Lateran Council.

[29] In 1310, Archbishop Porchetto Spinola (1299–1321) held a provincial synod, in which the Statutes of Genoa pertaining to the imprisonment of persons for unpaid debts, including clerics, was debated.

[31] On 10 January 1421, Archbishop Pileo de' Marini (1400–1433) held a diocesan synod, which was chiefly concerned with the lives and conduct of the clergy.

In 1567, shortly after his installation as Archbishop, Cipriano Pallavicino (1567–1586) held a provincial synod in order to introduce into the Statutes of the diocese canons for reform, in accordance with the decrees of the Council of Trent.

[32] On 1 September 1588, under Cardinal Antonio Sauli (1586–1591), the Perpetual Administrator of the diocese of Genoa, a diocesan synod was held.

The Cardinal ordered the rectors and curates of the churches to read one chapter of the Constitutions to the people on every feast day.

[34] A diocesan synod was also held on 6 May 1683, with Archbishop Giulio Vincentio Gentili and Pope Innocent XI taking part.