The Roman Catholic Archdiocese of Nagpur (Latin: Nagpuren(sis)) is a Latin Rite Metropolitan archdiocese in central India, yet depends on the missionary Roman Congregation for the Evangelization of Peoples.

Its cathedral episcopal see is St. Francis de Sales Cathedral, in the city of Nagpur, in Maharashtra state.

As per 2014, it pastorally served 25,500 Catholics (0.2% of 12,360,000 total) on 59,042 km2 in 34 parishes and 12 missions with 142 priests (48 diocesan, 94 religious), 798 lay religious (265 brothers, 533 sisters) and 23 seminarians.

Its ecclesiastical province comprises the Metropolitan's own archbishopric and these Suffragan bishoprics, Latin Rite except one Syro-Oriental Rite: (all Latin Rite, initially missionary members of a Latin congregation)