The Roman Catholic Archdiocese of San Juan de Cuyo (Latin: Archidioecesis Sancti Ioannis de Cuyo) is a Latin rite metropolitan diocese in Argentina.

Its archiepiscopal seat is San Juan Cathedral (Spanish: Catedral de San Juan Bautista), dedicated to Saint John the Baptist, in San Juan, Argentina.

The city also has a minor basilica: the Basílica di Nuestra Señora de los Desamparados, or the Basilica of Our Lady of the Forsaken.

As per 2014, it pastorally served 638,183 Catholics (91.0% of 701,000 total) on 89,615 km² in 43 parishes and 216 missions with 96 priests (80 diocesan, 16 religious), 8 deacons, 85 lay religious (17 brothers, 68 sisters) and 21 seminarians.

The Metropolitan's suffragan sees are :