The finding of arcus juvenilis in combination with hyperlipidemia in younger men represents an increased risk for cardiovascular disease.

[2] Unilateral AS can be associated with contralateral carotid artery stenosis or decreased intraocular pressure in the affected eye.

The opaque ring in the cornea does not resolve with treatment of a causative disease process, and can create cosmetic concerns.

[1] AS is not an independent predictor of cardiovascular disease, as demonstrated by a prospective cohort study of 12,745 Danes aged 20-93 followed up for an average of 22 years.

[7] The presence of AS in men less than 50 years old(arcus juvenilis) in combination with an underlying condition causing hyperlipidemia has been shown to significantly increase the relative risk of mortality from cardiovascular disease and coronary artery disease, as demonstrated by a study following 6,069 Americans aged 30-69 for an average of 8.4 years.