[4] Having turned professional in 2008, Muciño won her first World title on 22 January 2011, defeating Chantel Cordova for the vacant IBF female flyweight belt when her opponent retired in round four of their fight at Arena Neza, Ciudad Nezahualcoyotl, Mexico.

[8][9][4] She lost the belt in her first defense on 19 September 2015, going down to a unanimous decision loss against Jessica Chávez at Emiliano Zapata Sports Center, Ecatepec de Morelos, Mexico.

[10][11] Muciño became a three-time world female flyweight champion when she claimed the WBO title thanks to a majority decision win over Monserrat Alarcón at Domo del Parque San Rafael, Guadalajara, Mexico, on 17 February 2018.

[12][13] After making two successful defences, she vacated the title[14] before becoming IBF female flyweight World champion on 29 October 2022, by dethroning Argentina's Leonela Paola Yúdica by split decision at Pechanga Arena, San Diego, California, USA.

[15][16] Muciño's reign lasted only one fight as in her next contest she suffered a fifth-round stoppage defeat to Gabriela Fundora at the Kia Forum, Inglewood, California, USA, on 21 October 2023.