Arena Națională has hosted concerts by Metallica, Guns N' Roses, Red Hot Chili Peppers, Depeche Mode, and Ed Sheeran.

The Arena Națională is currently the home ground of FCSB, the first Romanian football club with millions of followers on social media.

The old stadium was demolished between 18 December 2007 and 20 February 2008, although a symbolic removal of seats took place on 21 November 2007, after Romania defeated Albania 6–1 in a qualifying match for Euro 2008.

The construction phase generated some controversy over costs and delays, with Bucharest mayor Sorin Oprescu claiming that the works were 20 weeks behind schedule in May 2009.

This came after the original hosts, Sweden, did not classify esports as a sporting event, making it more difficult for players to procure visas to the country.

The highest audience for a football match was achieved at an exhibition game between Romania's "Golden Generation" and the "World Stars" team, ended with a 3-2 score, which brought 54.967 spectators at the stadium.

[19] Another match with a notable audience was between Romania and Switzerland on 21 November 2023, in the qualifying stage of the UEFA Euro 2024 final tournament.

With 50,224 people in the stands, Romania won 1–0, thus making it the winner of Group I and giving it a place in Pot 2 for the final tournament in Germany.