Originally, the Treaty of Friendship and Alliance was established with the State of Buenos Aires, within the United Provinces of the Río de la Plata.

During the 19th century and particularly during the 1820s, the relationship between these two states was active as the constant interaction between their respective leaders, Simón Bolívar and José de San Martín, was required to complete the total liberation of South America.

As evidence of the above, the former Argentine president Bartolomé Mitre wrote the following in his Historia de San Martín y de la emancipación suamericana: These two tendencies (the independences), concurrent at one point, –the general emancipation,—represented by two political and military hegemonies,—the Argentine and the Colombian, - constitute the last knot of the South American revolution... (San Martín) He concurs in the independence of Colombia, carries the flag of the Argentine-Chilean-Peruvian revolution to the foot of Pichincha, greeted by the Colombian liberators, who carry out a similar campaign plan, no less gigantic than his...On July 27, 1822, the Guayaquil Interview took place, a private meeting between the heads of state of the sovereign nations of the Río de la Plata and Gran Colombia.

[2] Likewise, General San Martín requested help from Bolívar to conclude the Southern Campaigns, a fact that is supported by the following letter that he sent to the Colombian liberator in 1821: Consequently, without the support of the army under your command, the operation being prepared for Intermediate Ports will not be able to achieve the advantages that were expected, if powerful forces do not call the enemy's attention elsewhere and thus the fight will be prolonged for an indefinite time.

Other historical events that highlight the active interaction between the governments of Argentina and Colombia include: the Colombian occupation of Upper Peru, the Auxiliary Expedition of Santa Cruz to Quito, the establishment of the Protectorate of San Martín and the emergence of the Republic of Bolívar.

[4] Colombia has maintained relations with Argentina, when it was the United Provinces of the Río de la Plata, since 1823; this relationship was due to Latin American attempts at international recognition in order to achieve total independence from the Spanish Empire.

[11][12] In 2013, the former commander general of the Armed Forces was appointed by President Juan Manuel Santos Calderón as the new Colombian ambassador to the Argentine Republic.

[20] During the escalation of the conflict, the Colombian president, Julio César Turbay, sent a letter to General Galtieri advising him that military action was not a good idea, so the official position of the head of state and the foreign ministry was to support Argentine claims if they did not opt for war.

[21] However, the government maintained neutrality in the war and constantly sent letters to Margaret Thatcher and Leopoldo Galtieri in which it asked to find a path to dialogue.

[22] However, in 1982, the countries that were part of the Andean Pact (Colombia, Venezuela, Peru, Ecuador and Bolivia) proposed various forms of assistance to Argentina, such as a complete break in relations with the United Kingdom, the creation of a Latin American committee to assist Argentina, which sought to provide economic aid, and even evaluating the possibility of offering military aid, as proposed by Bolivia.

[22] Under President Álvaro Uribe Vélez, Colombia has renewed its support for Argentina in its claim to the Malvinas archipelago, perhaps due to the weight that comes with being the only state in the region not to be fully aligned with its neighbors.

[26] Changing the traditional position of neutrality, on June 10, 2019, President Iván Duque expressed, during his official visit to Argentina, that Colombia fully supports "the legitimate rights of the Argentine Republic in the sovereignty dispute with the United Kingdom of Great Britain and Northern Ireland, relating to the Malvinas, South Georgia, South Sandwich Islands and the surrounding maritime spaces.

"[27] This statement put an end to the ambiguities in Colombia's position regarding the Falkland Islands and the country aligned itself with other South American nations to fully support Argentina.

Then, on May 25, 2013, Nobel Peace Prize winner and Argentine activist Adolfo Pérez Esquivel issued a statement in which he said: We must put an end to violence and fundamentally disarm armed consciences.

This agreement is based on sharing information to find victims and establish a work plan between the two agencies in charge of this crime, the Inter-institutional Committee to Combat Human Trafficking in Colombia and the Executive Committee against Trafficking in the Republic of Argentina;[33] for this work plan, a comparison was made between the legislations of these Latin American countries.

The new waves of illegal drug trafficking to the south of the continent have led Argentina to begin to play an important role in the chain of cocaine trade and production.

[citation needed] Likewise, this migratory process to Argentina is due to three main reasons: on the one hand, there are the interests of young people to go to study in the southern country, followed by job aspirations and finally, there is illegal immigration and human trafficking.