A voracious eater, it will attempt to swallow anything that moves close to its wide mouth, such as insects, rodents, passerine birds, snakes, lizards, and other frogs, even if this predator would suffocate in the process.

Dimorphism traits between the two sexes are size difference and males possessing dark pigmented throats and nuptial pads on the forelimbs.

In the wild, their typical diet would include rodents such as mice, passerine birds, small reptiles, other frogs, large spiders, and insects such as locusts.

If threatened by a larger animal such as a human, these frogs can deliver a painful bite as they have several odontoid projections (not teeth per se) along the bottom and upper jaw.

When kept as a pet, the horned frogs are usually fed a staple diet of calcium-dusted crickets when young and night crawlers as well as the occasional mouse as an adult; they also enjoy – depending on size – live fish.