It relocated to offices of its own in 1892, and as it grew, it became legally necessary to have the society succeed to the Argentine Medical Association, a name adopted by an assembly held on August 13, 1913.

The Buenos Aires city government granted it a valuable Santa Fe Avenue lot for the construction of new offices in 1917, and the following year, new headquarters were inaugurated.

Six societies comprised the association in 1919: internal medicine, surgery, biology, microbiology, radiology, and ophthalmology.

Dr. Carlos Mainini's tenure (1936–42) was marked by a notable expansion of the group's academic activities, including the establishment of the societies of orthopedic surgery, endocrinology, nutrition science, and mental health, as well as the Argentine Society of Medical History.

The institution grew to include 43 societies, 7 associations, and 25 committees; over 37,000 physicians (over a fourth of the nation's total) were members.

The association issues accreditation to health facilities nationwide, and since 1950, operates the school of Continuing Medical Education, which offers 60 courses to over 2,000 students yearly (including around 300 from overseas).

Its periodical, the Revista de la Sociedad Médica Argentina has been published since October 1891, and its library, opened in 1917, houses over 25,000 volumes.

In them, they develop conferences, round tables and complex clinical cases also for discussed by the attendees and encouraging colleague's diagnosis and medical treatment.