Lacakwanna scored again the next day, capturing the steamer Planter as the blockade runner attempted a dash from Mobile, Alabama, to Havana, Cuba, laden with cotton and resin.

Following duty along the Texas coast near Galveston in March and April 1864, Lackawanna returned to the blockade of Mobile early in May 1864 to prevent the escape of the Confederate ram CSS Tennessee.

On 9 July 1864, with Monongahela, Galena, and Sebago, she braved the guns of Fort Morgan to shell the steamer Virgin, a large blockade runner aground at the entrance of Mobile Bay.

Following the victory at Mobile Bay, Lackawanna continued to operate in the Gulf of Mexico, enforcing the blockade until after the end of the Civil War in April 1865.

[3] In 1867, she also surveyed what is now called Kure Atoll, to the west northwest of Midway, to produce more accurate charts of the reefs there, which had been causing shipwrecks.

On 16 March 1883 at Honolulu, Captain of the Hold Louis Williams jumped overboard and rescued a fellow sailor from drowning, for which he was awarded the Medal of Honor.