[2] Fatyma made her acting debut with a leading role in the 2012 Geo TV serial Kis Din Mera Viyah Howay Ga 2, and subsequently gained success with the following series Mar Jain Bhi To Kya (2012), Humnasheen (2013), Woh (2013), Kissey Apna Kahein (2014), Aik Pal (2015), Ishq Parast (2015), Aap Ke Liye (2016) and Yaar-e-Bewafa (2017).
After working as a model for a few months, she was offered a comic role in the 2012 Geo TV sitcom Kis Din Mera Viyah Howay Ga 2.
[14] She then starred in leading roles in several successful television series, including the melodramas Mar Jain Bhi To Kya (2012) and Paree (2013), the romance Kissey Apna Kahein (2014), and the religious drama Aik Pal (2015).
[14][15] Fatyma subsequently received widespread critical appraisal for portraying leading roles in the dramas Khilona (2015), Ishq Parast (2015), Aap Ke Liye (2016) and Yaar-e-Bewafa (2017).
[13][10] Besides acting, she serves as an ambassador for a number of brands such as Lipton Tea, Mobilink, Cadbury Perk and Nestle Cerelac.