She is the CEO and founder of Bell Family Medical Centers in the United States, and served as the African Union representative to the US from 2017 to 2019.

She did a residency in Family Medicine at Meharry Medical College in Nashville, Tennessee.

[8][9] From 2012 to 2016, Chihombori-Quao served as the Chair of the African Union-African Diaspora Health Initiative (AU-ADHI).

As the chair of the AU-ADHI her work involves mobilizing Africans in the Diaspora health professionals in assisting with Africa's continental healthcare crisis.

The "Wakanda One Village Project", is slated to consist of five African Centers of excellence in the five regions on the continent of Africa.

[10][11][12] On October 7, 2019, she received notice by letter that she was no longer ambassador for the African Union in Washington.

The letter, from African Union chair Moussa Faki Mahamat to Chihombori-Quao, dated October 7, 2019, was also published online.