The town of Novo Aripuanã is located on its banks where it merges into the Madeira River.

[4][5] In Mato Grosso to the south of the border with Amazonas the river defines the western boundary of the 227,817 hectares (562,950 acres) Igarapés do Juruena State Park, created in 2002.

[6] To the north of the Amazonas border it flows through the 224,291 hectares (554,240 acres) Aripuanã Sustainable Development Reserve, created in 2005.

North of the highway the river flows through the 751,302 hectares (1,856,510 acres) Aripuanã National Forest, a sustainable development unit created in 2016 in the last week before the provisional removal of president Dilma Rousseff.

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