He was a favourite of the people on account of his noble descent and handsome presence, and thus became an object of fear to Herod, who at first sought to ignore him entirely by debarring him from the high priesthood.
But his mother Alexandra, through intercession with Cleopatra and Mark Antony, compelled Herod to remove Ananelus from the office of high priest and appoint Aristobulus instead.
This surveillance proved so onerous that they sought to gain their freedom by taking refuge with Cleopatra.
As told by the Roman Jewish historian Josephus, their plans were betrayed, and the disclosure had the effect of greatly increasing Herod's suspicions against his brother-in-law.
As Herod dared not resort to open violence, he caused him to be drowned while he was bathing in a pool in Jericho during a banquet organized by Alexandra.