The southern segment begins in Quartzsite at its junction with U.S. Route 95, traveling north to Parker then following the Colorado River until past Lake Havasu City, and finally intersecting Interstate 40.

The northern segment (the Mohave Valley Highway) begins at the Colorado River bridge across from Needles, then goes directly northbound to Bullhead City, terminating at its junction with State Route 68 north of town.

[1] As the primary north–south highway through much of the Arizona side of the Colorado River, SR 95 is an important thoroughfare for residents in the cities and towns of that area.

[2] The road south of Quartzsite to San Luis was renumbered as part of U.S. Route 95 on June 27, 1960.

Route is the entry and exit road into Cattail Cove State Park, located a few miles southeast of Lake Havasu City, Arizona.